刘方,1989年6月生,山东聊城人,中国海洋大学医学博士,2018年7月入职聊城大学药学院,担任“药剂学”“药剂学实验”“药剂学专论”课程负责人,主持国家自然科学基金青年项目,副教授,硕士生导师。
联系方式:邮箱liufangcnn@163.com;手机 18254236121(微信同号)。
研究方向:
药物共晶的筛选与体内外成药性评价。通过共晶技术改善现有化药、农药、兽药、天然产物等存在的难溶、稳定性差、生物利用度低、毒性等问题,并对所制备共晶进行体外理化性质研究,体内PK、药效、毒性评价,筛选优势晶型;
纳米晶制剂的制备、工艺优化与成药性评价。将纳米晶技术应用于药物研发,实现药物增溶、缓控释,并将药物从固体制剂拓展至液体制剂、注射剂等临床应用领域;
传统片剂、胶囊剂及相关辅料、药剂学实验测试装置研发。
(一) 代表性文章:
1. Shu-Yun Hao, Jin-Yang Li, Chong-Qiang Mu, Deng-Shuo Liu, Yu Yang, Yan-Tuan Li, Tie-Min Liu, Xue-Kun Wang, and Fang Liu*. Hepatoprotective Pyrazinamide–Baicalein Cocrystal with a Rare Ratio of 7: 3[J]. Crystal Growth & Design, 2023, 23(2): 885-891.
2. Fang Liu; Ling-Yang Wang; Ming-Chao Yu; Yan-Tuan Li*; Zhi-Yong Wu; Cui-Wei Yan; A new cocrystal of isoniazid-quercetin with hepatoprotective effect: The design, structure, and in vitro/in vivo performance evaluation[J]. European Journal of Pharmaceutical Sciences, 2020, 144: 1-7.
3. Fang Liu, Fu-Bing Jiang, Yan-Tan Li*, Ren-Min Liu, Zhi-Yong Wu. Cocrystallization with syringic acid presents a new opportunity for effectively reducing the hepatotoxicity of isoniazid[J]. Drug Development and Industrial Pharmacy, 2020, 46: 988-995.
4. Fang Liu, Yu Song, Ya-Nan Liu, Yan-Tuan Li*, Zhi-Yong Wu, Cui-Wei Yan, Drug-bridge-drug ternary cocrystallization strategy for anti-tuberculosis drugs combination. Crystal Growth & Design, 2018, 18: 1283-1286.
5. Fang Liu, Ling-Yang Wang, Yan-Tuan Li*, Zhi-Yong Wu, Cui-Wei Yan, Protective effects of quercetin against pyrazinamide induced hepatotoxicity via cocrystallization strategy of complementary advantages. Crystal Growth & Design, 2018, 18: 3729-3733.