谢磊



硕士研究生导师

基本信息                                      

姓名:

职称: 副教授

学历: 博士研究生

电话: 13082787791

电子信箱:xielei0212@163.com;xielei@lcu.cn

出生年月:1991.02

研究方向:金属或有机催化新型环加成反应方法学;新型杂环药物活性分子开发

毕业学校: 中国农业大学

  1. 研究领域

1. 金属络合物有机小分子催化的环加成反应新方法,研究这些方法在杂环分子及复杂生物活性分子合成中的应用;

2. 合成具有重要生物活性的杂环化合物及天然产物,用于抗肿瘤活性研究,开展新药创制工作;

3. 设计合成新型抗体偶联药物的连接子片段,用于增强ADC药物的稳定性和疗效。

近年来,主持或参与国家自然科学基金3项,山东省自然科学基金3横向课题7和技术支持课题6入职聊城大学以来第一或通讯作者发表SCI论文10余篇。

  1. 发表论文(按时间倒序排列)

  1. Wanxing Liu, Yandong Lv, Xiuzheng Liu, Menghui Guo, Rui Yan, Lingang Wu, Lei Xie* and Zhaoxue Wang*, Phosphine-catalyzed [3 + 2]-annulation of Morita–Baylis–Hillman carbonates with benzofuran-derived azadienes: Synthesis of spiro-cyclopentane benzofurans, Tetrahedron, 2025, 182, 134703.

  2. Zhaoxue Wang, Menghui Guo, Ping Wu, Rui Yan, Guili Zhao, Ming Liu, Yilei Xiao, Lingang Wu and Lei Xie*, Catalyst-controlled switchable formal retro-Büchner reaction for the divergent synthesis of benzo[b]azepines and 1, 3-conjugated dienes, Tetrahedron, 2025, 169, 134378.

  3. Lingang Wu, Zhaoxue Wang, Yanling Qiao, Lei Xie* and Qingmin Wang*, Photoexcited nitroarenes for alkylation of quinoxalin-2(1H)-ones, Chemical Communications, 2024, 60, 11311-11314.

  4. Lingang Wu, Baochuan Guan, Zhaoxue Wang and Lei Xie*, Et3N-catalyzed [3 + 2] annulation reaction of β-oxo-acrylamides with diethyl 2-oxomalonates: facile access to oxazolidin-4-one derivatives, Chemistry Letters, 2024, 53, upae116.

  5. Wanxing Liu, Zhehui Mao, Daohuang Chong, Zhaoxue Wang, Keying Zhang, Lingang Wu and Lei Xie*, Lewis base-catalyzed [3 + 2] annulation of β-oxo-acrylamides with acyl isothiocyanates: facile access to 2-iminothiazolidin-4-one derivatives, Tetrahedron Letters, 2024, 140, 155022.

  6. Lei Xie*, Chenyi Zhao, Zhaoxue Wang, Zirui Chen, Yingying Zhao, Xinghan Liu, Xiangdong Xu, Wanxing Liu, Xiaojing Li and Lingang Wu, Synthesis of Polycyclic Imidazolidinones via Cascade [3 + 2]-Annulation of β-Oxo-acrylamides with Cyclic N-Sulfonyl Imines, The Journal of Organic Chemistry, 2023, 88, 15805-15816.

  7. Zhaoxue Wang, Ge Tian, Yuying Shi, Wanxing Liu, Xiangdong Xu, Xiaojing Li, Lingang Wu and Lei Xie*, Lewis base-catalyzed cascade [4 + 2]-annulation reaction of N-alkoxy acrylamides and acyl isothiocyanates: facile access to 2-imino-1,3-thiazinone derivatives, Organic & Biomolecular Chemistry, 2023, 21, 9200-9209.

  8. Lingang Wu, Haibo Zhou, Lei Sun, Jichun Cui, Wanxing Liu, Yanlan Wang and Lei Xie*, Visible Light-Induced Photocatalyst-Free Aromatic Amidation for the Synthesis of 3,4-Dihydroquinolin-2(1H)-ones, Russian Journal of Organic Chemistry, 2024, 60, 459-466.

  9. Lingang Wu, Lei Sun, Wanxing Liu, Jichun Cui, Yanlan Wang, Lei Xie*. Visible-Light-Induced Photocatalyst-Free Dearomative Amidation of Phenol Derivatives. Tetrahedron Letters, 2023, 108, 154637.

  10. Lei Xie*, Lei Sun, Ping Wu, Zhaoxue Wang, Chenyi Zhao, Lingang Wu, XiaojingLi, Zhenzhen Gao, Wanxing Liu, Shao-zhen Nie. Organocatalytic cascade nucleophilic/aza-Michael addition reactions: Metal-free catalytic strategy for the synthesis of hydantoins. Organic & Biomolecular Chemistry, 2023, 21, 2295-2300.

  11. Lei Xie*, Lina Hu, Ping Wu, Yunxu Zhao, Guiling Li, Jichun Cui, Zhenzhen Gao, Lingang Wu, Shaozhen Nie. [8+3]-Cycloaddition Reactions of Heptafulvenes or Azaheptafulvenes with α-Halohydroxamates. Asian Journal of Organic Chemistry, 2022, e202200202.

  12. Lei Xie*, Xuyang Zang, Wanxing, Liu,Ping Wu,Zhaoxue Wang, Chenyi Zhao,Zhenzhen Gao, Xiaojing Li, Shaozhen Nie, Lingang Wu. Catalyst-free 1, 6-conjugate addition of S-nucleophiles to para- quinone methides. Asian Journal of Organic Chemistry, 2022, e202200524.

  13. Lingang Wu, Lei Sun, Jichun Cui, Lei Xie*, Yanlan Wang*, Shaozhen Nie*. Visible-light-induced photocatalyst-free intramolecular sp3 C–H oxidation of 2 alkyl benzamides. Tetrahedron Letters, 2022, 107, 154093.

  14. Lei Sun, Jichun Cui, Shaozhen Nie, Lei Xie*, Yanlan Wang*, Lingang Wu*. NIS-Mediated Intramolecular sp3 C-H Oxidation of 2-Alkyl Substituted Benzamides. European Journal of Organic Chemistry, 2022, e202200505.

  15. Wenjie Lan, Rong‐chao Lei, Jiayu Luo, Zhaohai Qin, Bin Fu, Lei Xie*. A Facile Approach to Benzosultam-fused 4-Imidazolidinone Derivatives from N-Sulfonyl Ketimine and α-Halogenated Hydroxamates. ChemistrySelect, 2022, 7, e20210367.

  16. Lei Xie*, Sheng-nan Guo, Ping Wu, Zhenzhen Gao, Fang Liu, Chunhao Yuan. [3 + 3]-Cycloaddition of aza-oxyallyl cations with 1,4-dithiane-2,5-diols for the construction of 3- thiomorpholinones. Synthetic Communications, 2020, 50(9), 1375-1387.

  17. Lei Xie, Hongli Ma, Jiaqi Li, Xuan Yu, Zhaohai Qin, Bin Fu. Ni(II)-Catalyzed enantioselective Mukaiyama–Mannich reaction between silyl enol ethers and cyclic N-sulfonyl α-ketiminoesters. Organic Chemistry Frontiers, 2017, 4, 1858-1862.