基本情况

葛士坤，男，博士，1990年5月出生，讲师

邮箱geshikun2016@163.com

研究领域

从事免疫学、病理学和兽医学，主要涉及抗体库的构建和筛选，嵌合抗体的改造及优化，蛋白互作，抗体Fc片段融合蛋白，Fc偶联小分子药物。

学习经历

科研项目

国家自然科学基金，面上项目，82373329，CRISPR高通量筛选的PBRM1通过染色质重塑介导NSCLC对PD-L1单抗耐药的机制研究，2024-01-01至2027-12-31，在研，参与

代表性文章

1. Ge S, Alberto C. P. Dias, Zhang X. Engineered IgG Fc-conjugation prolongs the half-life of florfenicol and alleviates pneumonia in mice. Biochimie. 2024 Oct 18:S0300-9084(24)00240-2.

2. Ge S, Alberto C. P. Dias, Zhang X. Chimerism of avian IgY-scFv and truncated IgG-Fc: a novel strategy in cross-species antibody generation and enhancement. Immunology. 2024;172(1):46-60.  

3. Ge S, Wu R, Zhou T, Liu X, Zhu J, Zhang X. Specific anti-SARS-CoV-2 S1 IgY-scFv is a promising tool for recognition of the virus. AMB Express. 2022 Feb 12;12(1):18.  

4. Ge S, Zhang X, Zhong F, Liu X, Zhang X. Generation and evaluation of IgY-scFv based mimetics against canine parvovirus. Veterinary Research. 2021 May 13;52(1):70.

5. Ge S, Xu L, Li B, Zhong F, Liu X, Zhang X. Canine parvovirus is diagnosed and neutralized by chicken IgY-scFv generated against the virus capsid protein. Veterinary Research. 2020 Sep 3;51(1):110.  

6. Ge S, Yang Y, Chelliappan B, Antonysamy M, Zhong F, Zhang X. Evaluation of different IgY preparation methods and storage stability as potential animal feed supplement. Pakistan Journal of Zoology, 2020 52(6), p.2305.  

代表性专著

1. Ge S, Xu L, Zhang X. 2022. Chapter 16 - Therapeutic peptidomimetics for infectious diseases. In: Editor(s): Nir Qvit, Samuel J.S. Rubin. Peptide and Peptidomimetic Therapeutics. Academic Press. ISBN 9780128201411. https://doi.org/10.1016/B978-0-12- 820141-1.00006-6.

2. Ge S, Ferreira Júnior Á, Zhang X, Morgan PM. 2021. The Domestic Hen. In: IgY-Technology: Production and Application of Egg Yolk Antibodies. Springer, Cham. https://doi.org/10.1007/978-3-030-72688-1_2