一、基本情况

祝汉闯，男，1995年3月生，2024年6月于济南大学毕业获得工学博士学位，同年7月进入聊城大学药学与食品工程学院工作。目前参与山东省自然科学基金项目1项，发表中科院TOP期刊论文多篇，申请国家发明专利2项。

通讯地址：山东省聊城市东昌府区湖南路1号。

Emai: zhuhanchuang@lcu.edu.cn

二、研究领域

1. 新型诊疗一体化试剂、光敏分子的设计合成与应用。

2. 小分子荧光探针的构建及其在食品、生物系统中重要物质检测中的应用。

三、代表性文章

[1] Hanchuang Zhu, Ping Li,* Baocun Zhu,* Bo Tang,* et al. In situ observation of lysosomal hypobromous acid fluctuations in the brain of mice with depression phenotypes by two-photon fluorescence imaging. Analytical Chemistry. 2022, 94, 11783-11790.

[2] Hanchuang Zhu, Baocun Zhu,* et al. Rational design of a targetable fluorescent probe for visualizing H2S production under Golgi stress response elicited by monensin. Analytical Chemistry. 2020, 92, 1883-1889.

[3] Hanchuang Zhu, Baocun Zhu,* et al. Recent advances in 4-hydroxy-1,8-naphthalimide-based small-molecule fluorescent probes. Coordination Chemistry Reviews. 2021, 448, 214153.

[4] Hanchuang Zhu, Baocun Zhu,* et al. A new phenylsulfonamide-based Golgi-targeting fluorescent probe for H2S and its bioimaging applications in living cells and zebrafish. Chemical Communications. 2020, 56, 4086-4089.

[5] Hanchuang Zhu, Baocun Zhu,* et al. Portable ratiometric fluorescence analytical device for copper ions based on smartphone in environment and living organisms. Science of the Total Environment. 2023, 857, 159488.

[6] Hanchuang Zhu, Baocun Zhu,* et al. A reversible NIR fluorescent probe for monitoring of SO2 and formaldehyde in live cells and zebrafish. Sensors and Actuators B: Chemical. 2022, 366, 131962.

[7] Hanchuang Zhu, Baocun Zhu,* et al. A new isothiocyanate-based Golgi-targeting fluorescent probe for Cys and its bioimaging applications during the Golgi stress response. Bioorganic Chemistry. 2022, 122, 105741.

四、国家发明专利

[1] 祝汉闯、朱宝存等; 一种特异性分析高尔基体中硫化氢荧光探针制备与应用 201911291926.X

[2] 朱宝存、祝汉闯等; 一种检测溶酶体次溴酸荧光探针、制备方法与应用 202210804380.9