一、基本情况：

张勤秀 女  1989年4月出生  医学博士  讲师

通讯地址：山东省聊城市东昌府区湖南路1号

邮箱：qinxiuzhangmail@163.com

二、研究方向

主要从事纳米药物靶向治疗研究

三、主要学习及工作经历

2023年8月-至今  聊城大学 讲师

2019年-2023年 山东大学 药剂学专业 博士

2016年-2019年 聊城大学  生物化学与分子生物学专业 硕士

2013年-2016年 山东京卫制药有限公司 吸入剂药品研发 研究员

2009年-2013年 山东中医医药大学  制药工程专业  学士

四、代表性文章：

Qinxiu Zhang, Wenhui Ye, Ying Liu, Decao Niu, Xin Zhao, Genjv Li, Ying Qu, Zhongxi Zhao, S-allylmercapto-N-acetylcysteine ameliorates pulmonary fibrosis in mice via Nrf2 pathway activation and NF-κB, TGF-β1/Smad2/3 pathway suppression. Biomedicine & Pharmacotherapy.(IF 7.5, SCI 1区).

Qinxiu Zhang, Genju Li, Guozhi Zhao, Chongzheng Yan, Huaiyou Lv, Yaqing Fu, Yuhan Li, Zhongxi Zhao, Preparation and evaluation of inhalable S-allylmercapto-N-acetylcysteine and nintedanib co-loaded liposomes for pulmonary fibrosis. European Journal of Pharmaceutical Sciences.(IF 4.6, SCI 2区).

Qinxiu Zhang, Yanna Zhao, Yuping Zhao, Zhuang Ding, Zhiping Fan, Huaizhen

Zhang, Min Liu, Zhengping Wang, Jun Han. Effect of HPMCAS on recrystallization

inhibition of nimodipine solid dispersions prepared by hot-melt extrusion and dissolution enhancement of nimodipine tablets. Colloids and Surfaces B: Biointerfaces. (IF 6.0; SCI 2区).

Wenhui Ye, Huaiyou Lv, Qinxiu Zhang, Jianxiong Zhao, Xin Zhao, Guozhi Zhao, Zhongxi Zhao. A cisplatin and disulfiram co-loaded inclusion complex overcomes drug resistance by inhibiting cancer cell stemness in non-small cell lung cancer. Journal of Drug Targeting (IF 4.5, SCI 3区).

Yanna Zhao, Xuemei Xie, Yuping Zhao, Yan Gao, Chang Cai, Qinxiu Zhang, Zhuang Ding, Zhiping Fan, Huaizhen Zhang, Min Liu*, Jun Han*. Effect of plasticizers on manufacturing ritonavir/copovidone solid dispersions via hot-melt extrusion: Preformulation, physicochemical characterization, and pharmacokinetics in rats. Eur J Pharm Sci, (IF 4.6, SCI 2区).

Jin L, Liu C, Zhang N, Zhang R, Yan M, Bhunia A, Zhang Q, Liu M, Han J, Siebert HC. Attenuation of human lysozyme amyloid fibrillation by ACE inhibitor Captopril: A combined spectroscopy, microscopy, cytotoxicity and docking study[J]. Biomacromolecules, (IF 6.2, SCI 2区).

Dandan Zheng, Jinglong Wang , Genju Li, Lulu An, Ying Qu, Qinxiu Zhang,

Wenhui Ye , Xin Zhao , Zhongxi Zhao,S-Allylmercapto-N-acetylcysteine ameliorates elastase-induced chronic obstructive pulmonary disease in mice via regulating autophagy.  Biochemical and Biophysical Research Communications, (IF 3.1, SCI 3区).

五、专利

韩军，张勤秀，赵燕娜，王正平，刘敏，一种尼莫地平固体分散体及其片剂制备方法。专利号：201711390110。