姓 名: 魏福尧
性 别: 男
出生日期: 1990/01/15
家庭住址: 吉林省白山市浑江区
政治面貌: 党员
专 业: 生药学、细胞生物学
电 话: 13596058166
电子邮件: weify753@nenu.edu.cn
研究方向: 天然产物提取分离鉴定及其抗肿瘤、抗菌等生物学活性研究
___教育背景______________________________________________________________________________
2007年9月—2011年6月 河北科技大学 生命科学学院 生物科学 理学学士
2012年9月—2015年6月 东北林业大学 森林植物生态学教育部重点实验室 生药学 医学硕士导师:付玉杰(长江学者)
2015年9月—2021年6月 东北师范大学 药物基因与蛋白筛选国家工程实验室 细胞生物学 理学博士导师:李玉新 鲍永利(两任实验室主任)
___科研内容_______________________________________________________________________________
1. 中药中天然活性产物的高效提取、系统分离、纯化及鉴定;
2. 药食同源植物中多糖的高效提取、纯化、分离、结构解析、高级结构分析;
3. 多糖体外抗氧化活性,细胞抗氧化活性、免疫调节活性与修复细胞氧化损伤能力的评估;
4. 中药中精油类成分的组分分析与鉴定、及其抗菌活性的评估;
5. 植物油脂类成分的提取,抗氧化活性,组分分析及生物柴油的相关研究;
6. 板蓝根无菌苗的培养及其毛状根诱导的相关实验;
7. 中药活性成分的高效提取与检测方法学研究。
___科研技能_______________________________________________________________________________
1. 掌握基于多种柱色谱系统的分离和纯化天然活性产物的方法;
2. 熟练掌握各类HPLC、LC-MS-MS、GC、GC-MS、红外光谱、紫外光谱、酶标仪等检测仪器的使用方法和检测原理,能够独立建立检测方法并准确分析结果;
3. 掌握多糖类成分结构解析与高级结构的研究方法,包括衍生化修饰、NMR解析、扫描电镜、原子力显微镜、圆二色谱等技术手段,并独立分析实验结果;
4. 掌握多种细胞系的体外培养与活性评估方法;
5. 掌握多种抗肿瘤、抗氧化活性,抗炎活性和抗菌活性评估的研究方法,了解抗肿瘤活性机制的研究方法。
6. 了解组内关于生物信息学、药物作用通路,药物制剂,药物合成,生物转化,生物诱导,植物内生真菌和生物柴油催化的相关研究内容和方法;
7. 熟练掌握Statistica, Origin, Design-Expert, ChemDraw等科研软件的使用方法。
___主要科研成果_____________________________________________________________________________
1. Wei, F., Zhu, H., Li, N., Yu, C., Song, Z., Wang, S., ... & Sun, L. (2021). Stevioside Activates AMPK to Suppress Inflammation in Macrophages and Protects Mice from LPS-Induced Lethal Shock. Molecules, 26(4), 858. (IF=4.441,三区,一作)
2. Wang, F., Yuan, J., Li, J., Liu, H., Wei, F., & Xuan, H.. (2022). Antibacterial activity of chinese propolis and its synergy with β-lactams against methicillin-resistant staphylococcus aureus. Brazilian Journal of Microbiology, 53(4), 1789-1797. (IF=2.214,三区,共同通讯)
3. Shao, X., Liu, L., Wei, F., Liu, Y., Wang, F., Yi, J., ... & Li, Y. (2020). Fas and GIT1 signalling in the prefrontal cortex mediate behavioural sensitization to methamphetamine in mice. Brain Research Bulletin, 164, 361-371. (IF=4.077,三区)
4. Wang, F., Wei, F., Song, C., Jiang, B., Tian, S., Yi, J., ... & Li, Y. (2017). Dodartia orientalis L. essential oil exerts antibacterial activity by mechanisms of disrupting cell structure and resisting biofilm. Industrial Crops and Products, 109, 358-366. (IF=5.645,一区,共同一作)
5. Wang, P., Peng, X., Wei, Z. F., Wei, F. Y., Wang, W., Ma, W. D., ... & Zu, Y. G. (2015). Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway. Biochimica et Biophysica Acta (BBA)-General Subjects, 1850(9), 1751-1761. (IF=3.770,三区)
6. Zhang, D. Y., Yao, X. H., Duan, M. H., Wei, F. Y., Wu, G. H., & Li, L. (2015). Variation of essential oil content and antioxidant activity of Lonicera species in different sites of China. Industrial Crops and Products, 77, 772-779. (IF=5.645,一区)
7. Jiao, J., Wei, F. Y., Gai, Q. Y., Wang, W., Luo, M., Fu, Y. J., & Ma, W. (2014). A pilot-scale homogenization-assisted negative pressure cavitation extraction of Astragalus polysaccharides. International journal of biological macromolecules, 67, 189-194. (IF=6.953,二区,共同一作)
8. Wang, X. Q., Wei, F. Y., Wei, Z. F., Zhang, L., Luo, M., Zhang, Y. H., ... & Fu, Y. J. (2014). Homogenate-assisted negative-pressure cavitation extraction for determination of organic acids and flavonoids in honeysuckle (Lonicera japonica Thunb.) by LC–MS/MS. Separation and Purification Technology, 135, 80-87. (IF=7.312,二区,共同一作)
9. Jiao, J., Li, Z. G., Gai, Q. Y., Li, X. J., Wei, F. Y., Fu, Y. J., & Ma, W. (2014). Microwave-assisted aqueous enzymatic extraction of oil from pumpkin seeds and evaluation of its physicochemical properties, fatty acid compositions and antioxidant activities. Food chemistry, 147, 17-24. (IF=7.514,二区)
10. Jiao, J., Gai, Q. Y., Wei, F. Y., Luo, M., Wang, W., Fu, Y. J., & Zu, Y. G. (2013). Biodiesel from forsythia suspense [(Thunb.) vahl (Oleaceae)] seed oil. Bioresource technology, 143, 653-656. (IF=9.642,一区)
11. Gai, Q. Y., Jiao, J., Wei, F. Y., Luo, M., Wang, W., Zu, Y. G., & Fu, Y. J. (2013). Enzyme-assisted aqueous extraction of oil from Forsythia suspense seed and its physicochemical property and antioxidant activity. Industrial Crops and Products, 51, 274-278. (IF=5.645,一区)
12. Jiao, J., Gai, Q. Y., Luo, M., Wang, W., Gu, C. B., Zhao, C. J., ... & Fu, Y. J. (2013). Comparison of main bioactive compounds in tea infusions with different seasonal Forsythia suspensa leaves by liquid chromatography–tandem mass spectrometry and evaluation of antioxidant activity. Food research international, 53(2), 857-863. (IF=6.475,二区)
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