一、基本情况
张恩祥（1990-08）男，食品科学与工程专业博士，生命科学博士后，副教授，硕士研究生导师，聊城市优秀人才。
E-mail: zhangenxiang0728@163.com
二、学习及工作经历
2010.9-2014.7 聊城大学 食品科学与工程专业 本科
2017.9-2019.9 美国明尼苏达大学-双城校区 联合培养博士生
2014.9-2020.7 中国农业大学 食品科学与工程 博士研究生
2020.8-2022.8 浙江高等研究院（西湖大学）博士后助理研究员
2022.9-2023.3 美国杜克大学 博士后助理研究员
2023.3-2023.9 美国俄亥俄州立大学 副研究员
2023.10-至今 聊城大学药学院 副教授
三、 研究方向以及承担课题
近年来参与国家自然科学基金面上项目1项，重大专项1项，主持聊城大学高层次人才启动基金1项、国自然青年基金1项、山东省自然科学基金青年项目1项；以第一或通讯作者发表SCI论文10余篇。主要研究方向为：
（1）天然产物活性成分以及活性筛选；
（2）环境污染物的毒理学机制研究；
（3）表观遗传调控在肿瘤以及代谢性疾病中的作用研究；
欢迎优秀学子加入本团队，开展研究生阶段的学习！
四、代表论文
1) Enxiang Zhang, Wenqi Cui, Michael Lopresti, Mara T. Mashek, Hongbo Hu* and Douglas G. Mashek*. Hepatic PLIN5 signals via SIRT1 to promote autophagy and prevent inflammation during fasting. Journal of lipid research.
2) Enxiang Zhang, Shutao Yin, Shuang Zhao, Chong Zhao, Mingzhu Yan, Lihong Fan and Hongbo Hu. Protective effects of glycycoumarin on liver diseases. Phytotherapy Research.
3) Enxiang Zhang, Charles P Najt, Hongbo Hu and Douglas G. Mashek.Hepatic perilipin 5 promotes lipophagy and alters lipid droplet and mitochondrial dynamics. The FASEB journal.
4) Enxiang Zhang, Xiuling Wang, Xiaoyi Liu, Min Liang, Hongbo Hu and Shutao Yin*. 3’- desmethyarctigenin induces G2/M cell cycle arrest and apoptosis through ROS generation in hepatocarcinoma cells. Phytotherapy Research.
5) Enxiang Zhang, Xiaotong Lu, Shutao Yin, Mingzhu Yan, Shangyun Lu, Lihong Fan and Hongbo Hu*. The functional role of Bax/Bak in palmitate-induced lipoapoptosis. Food and chemical Toxicology.
6) Enxiang Zhang, Shutao Yin, Xiaotong Lu, Linhu Ye, Lihong Fan and Hongbo Hu*. Glycycoumarin sensitizes liver cancer cells to ABT-737 by targeting de novo lipogenesis and TOPK-survivin axis. Nutrients.
7) Enxiang Zhang, Xinhua Song, Shutao Yin, Lihong Fan* and Hongbo Hu*. Glycycoumarin prevents hepatic steatosis through activation of adenosine 5'- monophosphate (AMP)-activated protein kinase signaling pathway and up-regulation of BTG/Tob-1.Journal of functional foods.
8) Enxiang Zhang, Shutao Yin, Xinhua Song, Lihong Fan, Min Ye and Hongbo Hu*. Glycycoumarin protects against hepatocyte lipoapoptosis through activation of autophagy and inhibition of ER stress/GSK-3-JNK/CHOP-mitochondria cascade. Scientific reports.
9) Enxiang Zhang, Shutao Yin, Chong Zhao, Lihong Fan, *and Hongbo Hu*. Involvement of activation of PLIN5-Sirt1 axis in protective effect of glycycoumarin on hepatic lipotoxicity. Biochemical and Biophysical Research Communications.
10) Enxiang Zhang#*, Yang Zhao# and Hongbo Hu*. Impact of sodium glucose cotransporter 2 (SGLT2) inhibitors on non-alcoholic fatty liver disease complicated by diabetes mellitus. Hepatology communications. (通讯作者)
11) Han Zhang, Enxiang Zhang* and Hongbo Hu*. Role of ferroptosis in NAFLD and its implications for therapeutic strategies. Biomedicines. (通讯作者)
