王印虎
一、基本情况
王印虎,男, 1988年7月6日出生,博士毕业于山东大学药学院,副教授,硕士生导师。
教学上,主要从事“药物设计学”、“新药设计开发与注册申报” “药学综合设计实验”等理论/实验课程教学。
科研上,主持国家自然基金青年基金1项,山东省重点研发项目1项,聊城大学重大纵向项目培育计划项目1项,聊城大学博士启动基金1项。发表高水平学术论文20余篇, 授权2项中国发明专利。
通讯地址:山东省聊城市东昌府区湖南路1号
Email: wangyinhuabc@126.com
二、研究领域
1. 基于靶点结构(例如,细菌外排蛋白AcrB和抗菌肽模拟物等)的抗耐药菌小分子化合物的设计、合成、抗菌活性研究;
2. 复杂结构抗生素的合成、修饰和构效关系研究;
3. 复杂抗菌及抗耐药机理研究。
三、工作及学习经历
2024.01-至今 聊城大学药学与食品工程学院 副教授
2018.07-2023.12 聊城大学药学院 讲师
2014.09-2018.06 山东大学 博士
2012.09-2014.06 华中科技大学 硕士
2008.09-2012.06 济宁医学院 学士
四、科研项目
1. 基于膜透化与AcrB抑制双功能抗菌化合物的设计、合成及活性研究, 国家自然科学基金(81903449),20万,主持。
2. 具有逆转细菌耐药活性的AcrB抑制剂的研究,山东省重点研发计划项目(2019GSF108051),15万,主持。
3. AcrB外排泵抑制剂的发现及其逆转细菌多重耐药性研究,国家自然科学基金(81973179), 55万,参与。
4. 苯并色烯类AcrB抑制剂的设计,合成及逆转耐药研究,聊城大学博士启动基金,8万,主持。
5. 抗体26F8偶联抗菌药物的设计及其抗菌活性评价(318062306),聊城大学重大纵向项目培育计划,10万,主持。
五、代表性文章及专利
[1] Siyu Yang, Guoqing Miao, Xinyu Wang, Fen Zhou, Ziheng Yuan, Fuyao Wei, Lusha Ji, Xuekun Wang, Gaopan Dong*, Yinhu Wang*. Development of membrane-targeting chalcone derivatives as antibacterial agents against multidrug-resistant bacteria, European Journal of Medicinal Chemistry, 2024, 280: 116969. (IF = 6.00)
[2] Fangquan Liu#, Siyu Yang#, Lei Zhang, Meiyue Zhang, Ying Bi, Shuo Wang, Xuekun Wang*, Yinhu Wang*. Design, synthesis and biological evaluation of amphiphilic benzopyran derivatives as potent antibacterial agents against multidrug-resistant bacteria, European Journal of Medicinal Chemistry, 2024, 277: 116784. (IF = 6.00)
[3] Siyu Yang#, Fangquan Liu#, Yue Leng, Meiyue Zhang, Lei Zhang, Xuekun Wang*, Yinhu Wang*. Development of xanthoangelol-derived compounds with membrane-disrupting effects against Gram-positive bacteria, Antibiotics, 2024,13: 744. (IF = 4.30)
[4] Yinhu Wang*, Guoqing Miao, Shuo Wang, Fen Zhou*. Design, synthesis, and evaluation of pyranochromene derivatives as membrane targeting antibacterials against Gram-positive bacteria, Bioorganic & Medicinal Chemistry Letters, 2024, 113: 129949. (IF = 2.50)
[5] Fangquan Liu#, Chongqiang Mu#, Fen Zhou*, Yinhu Wang*. Novel resveratrol derivatives as potent membrane-active antibacterial agents, Phytochemistry Letters, 2023, 57: 78–82. (IF = 1.70)
[6] Yinhu Wang#, *, Ping Wu# , Fangquan Liu, Junjie Chen, Jie Xue, Yinhui Qin, Fang Chen, Shuo Wang*, Lusha Ji*. Design, synthesis, and biological evaluation of membrane-active honokiol derivatives as potent antibacterial agents, European journal of medicinal chemistry, 2022, 240:114593. (IF = 7.088)
[7] Yinhu Wang#, Rawaf Alenazy#, Xinjie Gu, Steven W Polyak, Panpan Zhang, Matthew J Sykes, Na Zhang, Henrietta Venter*, Shutao Ma*. Design and structural optimization of novel 2H-benzo[h]chromene derivatives that target AcrB and reverse bacterial multidrug resistance. European Journal of Medicinal Chemistry, 2021, 213, 113049. (IF = 6.514)
[8] Yinhu Wang# *, Chen Qu#, Tingting Liu, Chunhui Wang*. PFKFB3 inhibitors as potential anticancer agents: Mechanisms of action, current developments, and structure-activity relationships. European Journal of Medicinal Chemistry, 2020, 203, 112612. (IF = 5.572)
[9] Yinhu Wang#, Rawaf Alenzy#, Di Song, Xingbang Liu, Yuetai Teng, Rumana Mowla, Yingang Ma, Steven W. Polyak, Henrietta Venter*, Shutao Ma*. Structural optimization of natural product nordihydroguaretic acid to discover novel analogues as AcrB inhibitors. European Journal of Medicinal Chemistry, 2020, 186, 15, 111910. (IF = 5.572)
[10] Yinhu Wang#, Rumana Mowla#, Liwei Guo, Miguel A. De Barros Lopes, Chaobin Jin, Di Song, Shutao Ma* & Henrietta Venter*. Design, synthesis and biological activity evaluation of novel 4-subtituted 2-naphthamide derivatives as AcrB inhibitors. European Journal of Medicinal Chemistry, 2018, 43, 1: 699-709. (IF = 4.816)
[11] Yinhu Wang, Chao Cong, Wern Chern Chai, Ruiqian Dong, Li Jia, Di Song, Ziteng Zhou, Shutao Ma*. Synthesis and antibacterial activity of novel 4"-O-(1-aralkyl-1,2,3-triazol-4-methyl-carbamoyl) azithromycin analogs. Bioorganic & Medicinal Chemistry Letters, 2017, 27: 3872–3877. (IF = 2.454)
[12] Yinhu Wang#, Rumana Mowla#, Liwei Guo, Abiodun D. Ogunniyi, Taufiq Rahman, Miguel A. De Barros Lopes, Shutao Ma*, Henrietta Venter*. Evaluation of a series of 2-napthamide derivatives as inhibitors of the drug efflux pump AcrB for the reversal of antimicrobial resistance. Bioorganic & Medicinal Chemistry Letters, 2017, 27, 4: 733-739. (IF = 2.454)
[13] Yinhu Wang, Henrietta Venter, Shutao Ma*. Efflux Pump Inhibitors: A Novel Approach to Combat Efflux-Mediated Drug Resistance in Bacteria. Current Drug Targets, 2016, 17, 6: 702-719. (IF = 3.236)
[14] 王印虎,陈军节,刘方全,薛洁.具有抗菌增敏活性的双芳基衍生物及其在抗菌中的应用,2023-11-14, 中国, ZL202210223119.X.
[15] 王印虎, 刘方全, 陈军节, 薛洁, 朱冰雪, 周焕焕, 李超, 韦桂云. 具有广谱抗菌活性的和厚朴酚类抗菌肽模拟物及其制备方法, 2023-11-03, 中国, ZL202210223350.9.