张恩祥（1990-08）男，博士，副教授
联系方式:15652680799
E-mail: zhangenxiang0728@163.com
教育背景
2010.9-2014.7 本科就读于聊城大学食品科学与工程专业，获得工学学士学位
2014.9-2020.7博士就读于中国农业大学食品科学与营养工程学院，获得工学博士学位
工作经历
2020.8-2022.8 浙江高等研究院（西湖大学）博士后助理研究员
2022.9-2023.3 美国杜克大学 博士后助理研究员
2023.3-2023.9 美国俄亥俄州立大学 副研究员
2023.10-至今 聊城大学药学院 副教授
教学工作
《细胞生物学》、《现代分子生物学》
研究方向
天然产物活性成分生物活性筛选；
表观遗传调控在肿瘤以及代谢性疾病中的作用研究；
核心技术
代谢性疾病以及肿瘤模型的构建，基因编辑技术，类器官培养
参与项目
表观遗传调控在肝脏再生修复中的作用机制研究，国家自然科学基金委，重大研究计划，92068103，2021-01-01至2023-12-31，80万，在研，参与
代表论文
主要从事代谢性疾病机制研究， 共发表SCI论文16篇，第一作者论文9篇，通讯作者发表综述2篇。
1) Enxiang Zhang, Wenqi Cui, Michael Lopresti, Mara T. Mashek, Hongbo Hu* and Douglas G. Mashek*. Hepatic PLIN5 signals via SIRT1 to promote autophagy and prevent inflammation during fasting. Journal of lipid research.
2) Enxiang Zhang, Shutao Yin, Shuang Zhao, Chong Zhao, Mingzhu Yan, Lihong Fan and Hongbo Hu. Protective effects of glycycoumarin on liver diseases. Phytotherapy Research.
3) Enxiang Zhang, Charles P Najt, Hongbo Hu and Douglas G. Mashek.Hepatic perilipin 5 promotes lipophagy and alters lipid droplet and mitochondrial dynamics. The FASEB journal.
4) Enxiang Zhang, Xiuling Wang, Xiaoyi Liu, Min Liang, Hongbo Hu and Shutao Yin*. 3’- desmethyarctigenin induces G2/M cell cycle arrest and apoptosis through ROS generation in hepatocarcinoma cells. Phytotherapy Research.
5) Enxiang Zhang, Xiaotong Lu, Shutao Yin, Mingzhu Yan, Shangyun Lu, Lihong Fan and Hongbo Hu*. The functional role of Bax/Bak in palmitate-induced lipoapoptosis. Food and chemical Toxicology.
6) Enxiang Zhang, Shutao Yin, Xiaotong Lu, Linhu Ye, Lihong Fan and Hongbo Hu*. Glycycoumarin sensitizes liver cancer cells to ABT-737 by targeting de novo lipogenesis and TOPK-survivin axis. Nutrients.
7) Enxiang Zhang, Xinhua Song, Shutao Yin, Lihong Fan* and Hongbo Hu*. Glycycoumarin prevents hepatic steatosis through activation of adenosine 5'- monophosphate (AMP)-activated protein kinase signaling pathway and up-regulation of BTG/Tob-1.Journal of functional foods.
8) Enxiang Zhang, Shutao Yin, Xinhua Song, Lihong Fan, Min Ye and Hongbo Hu*. Glycycoumarin protects against hepatocyte lipoapoptosis through activation of autophagy and inhibition of ER stress/GSK-3-JNK/CHOP-mitochondria cascade. Scientific reports.
9) Enxiang Zhang, Shutao Yin, Chong Zhao, Lihong Fan, *and Hongbo Hu*. Involvement of activation of PLIN5-Sirt1 axis in protective effect of glycycoumarin on hepatic lipotoxicity. Biochemical and Biophysical Research Communications.
10) Enxiang Zhang#*, Yang Zhao# and Hongbo Hu*. Impact of sodium glucose cotransporter 2 (SGLT2) inhibitors on non-alcoholic fatty liver disease complicated by diabetes mellitus. Hepatology communications. (通讯作者)
11) Han Zhang, Enxiang Zhang* and Hongbo Hu*. Role of ferroptosis in NAFLD and its implications for therapeutic strategies. Biomedicines. (通讯作者)
