硕士生导师简历
基本信息
姓名： 刘国运
职称： 副教授
学历： 博士研究生
电话： 15063505132
电子信箱：guoyunliu@126.com
出生年月：1985年3月
研究方向： 活性天然产物导向的抗药药物设计、合成及其活性机制研究
毕业学校： 兰州大学
职务： 药学院副院长
研究工作简介
基于天然产物活性片段，运用药物设计策略设计合成目标分子，评价抗肿瘤活性；运用生物化学与分子生物学手段探讨其抗肿瘤活性机制，并通过体内实验评价其成药性。主持山东省抗体制药协同创新中心开放课题1项，聊城大学博士启动基金1项，参与山东省自然科学基金2项；获聊城大学优秀自然科学成果二等奖2项；指导研究生获山东省研究生优秀成果奖三等奖2项；近几年，在国内外重要期刊Bioorganic Chemistry，European Journal of Pharmaceutical Sciences等发表SCI论文10余篇。
发表论文（按时间倒序排列）
1. Yue Liu, Peng-Xiao Li, Wen-Wen Mu, Ya-Lei Sun, Ren-Min Liu, Jie Yang,* and Guo-Yun Liu*, Design, Synthesis, and Anticancer Activity of Cinnamoylated Barbituric Acid Derivatives. Chemistry Biodiversity, 2022, 19, e202100809. SCI三区
2. Ai-Ling Sun, Wen-Wen Mu, Yan-Mo Li, Ya-Lei Sun, Peng-Xiao Li, Ren-Min Liu, Jie Yang,*
and Guo-Yun Liu, Piperlongumine Analogs Promote A549 Cell Apoptosis through Enhancing ROS Generation. Molecules, 2021, 26, 3243. SCI三区3
3. Peng‑Xiao Li, Yan‑Mo Li, Wen‑Wen Mu, Ya‑Lei Sun, Yan Li, Jie Yang, Ren‑Min Liu, Guo‑Yun Liu, Cinnamic acid/β‑ionone hybrids: synthesis and in vitro anticancer activity evaluation. Monatshefte für Chemie - Chemical Monthly, 2021, 152, 863-870. SCI四区
4. Jie Yang, Wen-Wen Mu, Yu-Xin Cao, Guo-Yun Liu⁎，Synthesis and biological evaluation of β-ionone oriented proapoptosis agents by enhancing the ROS generation. Bioorganic Chemistry, 2020, 104, 104273. SCI一区
5. Jie Yang **, Wen-Wen Mu , Guo-Yun Liu*,Synthesis and evaluation of the anticancer activity of bischalcone analogs in human lung carcinoma (A549) cell line. Eur. J. Pharmacol. 2020, 888, 173396. SCI三区
6. Wen-Wen Mu, Peng-Xiao Li, Yue Liu, Jie Yang, Guo-Yun Liu*, The potential role of the 5,6-dihydropyridin-2(1H)-one unit of piperlongumine on the anticancer activity. RSC Advances. 2020, 10, 42128-42136. SCI三区
7. Wen-Wen Mu, Yu-Xin Cao, Xiao-Ru Tie, Ting LI, Zhen-Zhen Zhu, Jie YANG* & Guo-Yun Liu*, Fluorined Mono-carbonyl Curcumin Analogues Induce Reactive Oxygen Species to Enhance Apoptosis in Human Colon Cancer HCT116 Cells. Latin American Journal of Pharmacy 2020, 39, 361-365. SCI四区
8. Jie Yang*, Wen-Wen Mu, Rui-Ya Jiang, Xiang-Qun Yao, Chen-Lu Niu, Sheng-Di Lu & Guo-Yun Liu*, 2,2’-Hydroxyl Mono-carbonyl Curcumin Induces Apoptosis and ROS Generation in HepG2 Cells In Vitro. Latin American Journal of Pharmacy 2020, 39, 79-82. SCI四区
9. Jie Yang, Jing Li, Xiao-Yu Qu, Guo-Yun Liu*, Ren-Min Liu*, A Novel Resveratrol Derivative Induces Oxidative Stress, G1 Cell Cycle Arrest and Premature Senescence in A549 Cells. Latin American Journal of Pharmacy 2019, 38, 907-917. SCI四区
10. Jie Yang*, Feng-Ling Liu, Yu-Xin Cao, Ya-Ru Li & Guo-Yun Liu*, 3,5-Dihydroxy-4’-fluoro-trans-stilbenzen Inhibits the Proliferation of A549 Cells via G1 Cell Cycle Arrest and Premature Senescence. Latin American Journal of Pharmacy 2019, 38, 1838-1845. SCI四区
11. Jie Yang* Su-Su Meng, Yong-Jing Zhao, Guang-Yong Li, Ling-Yun Ge, Hua-Lei Zhang, and Guo-Yun Liu, 3,5-BIS(2-TRIFLUOMETHOXYBENZYLIDENE)-4-PIPERIDONE INDUCES APOPTOSIS IN A549 CELLS THROUGH REACTIVE OXYGEN SPECIES-MEDIATED PATHWAYS. Pharmaceutical chemistry Journal, 2019, 53, 593-597. SCI四区
12. 杨 杰，牟文文，郝海爽，王雅男，徐莹莹，刘国运*，硝基取代姜黄素类似物的合成及其对肝癌细胞的凋亡诱导活性，国际药学研究杂志，2019，46，467-471. 北大中文核心
13. Hua-Lei Zhang, Xiao-Lu Ren, Wen-Hua Yang, Yu, Xie,Jie Yang, Shang-Jing Guo, Guo-Yun Liu*, Synthesis and Evaluation of Anti-Cancer Activities of Mono-Carbonyl Curcumin Analogs. Latin American Journal of Pharmacy 2018, 37, 958-963. SCI四区
14. Guo-Yun Liu, Cong-Cong Jia, Pu-Ren Han, Jie Yang*, 3,5-Bis(2- fluorobenzylidene)-4-piperidone induce reactive oxygen species-mediated apoptosis in A549 cells. Medicinal Chemistry Research 2018, 27, 128-136. SCI四区
15. 刘国运，张琦，薛云霞，杨杰*，含哌啶酮结构单元的姜黄素类似物的合成及诱导癌细胞凋亡活性研究。2018，26，354-359. 北大中文核心
16. 杨 杰，赵永晶，李晓静，孟素素，张华磊，刘国运*，三氟甲基取代单羰基姜黄素的合成及其对肺癌细胞的抗增殖活性，国际药学研究杂志，2018，45，593-596. 北大中文核心
