硕士生导师简历

1. 基本信息                                      

姓名： 李晓静

职称： 副教授

学历： 博士

电话：13869559712

电子信箱：xiaojingli945@vip.163.com

出生年月：1986年9月

研究方向：1. 天然抗肿瘤活性化合物的分离分析、结构修饰和机制研究

         2. 间充质干细胞药物的开发及作用机制研究

毕业学校： 沈阳药科大学

职务： 无

1. 研究工作简介

李晓静，女，药物化学博士、聊城大学药学院副教授、硕士研究生导师。课题组的研究领域包括：（1）基于天然活性化合物，针对恶性肿瘤相关药物靶标，进行药物设计、合成及生物活性评价和机制研究；（2）间充质干细胞的成药性和作用机理研究。作为项目负责人主持了国家自然科学基金1项，中国博士后基金1项，山东省自然科学基金1项，山东省抗体制药协同创新中心开放课题1项，聊城大学科研项目2项、教改项目1项。目前已在European Journal of Medicinal Chemistry，European Journal of Pharmacology，Organic & Biomolecular Chemistry等期刊发表论文10余篇，授权发明专利1项，获得聊城大学科学技术奖二等奖1项。

1. 发表论文（按时间倒序排列）

1. Xiaojing Li, Yulei Dong, Han Yin, Zhanfeng Qi, Dawei Wang*, Shaoda Ren*, Mesenchymal stem cells induced regulatory dendritic cells from hemopoietic progenitor cells through Notch pathway and TGF-β synergistically, Immunology Letters, 2020,222: 49-57.

2. Xiaojing Li*, Jie Ding, Ning Li, Wenxia Liu, Fuhao Ding, Huijuan Zheng, Yanyan Ning, Hongmin Wang, Renmin Liu*, Shaoda Ren*, Synthesis and biological evaluation of celastrol derivatives as anti-ovarian cancer stem cell agents, European Journal of Medicinal Chemistry, 2019, 179: 667-679.

3. Xiaojing Li*, Yihua Liu, Na Wang, Yuyu Liu, Shuai Wang, Hongmin Wang, Aihua Li, Shaoda Ren*, Synthesis and discovery of 18b-glycyrrhetinic acid derivatives inhibiting cancer stem cell properties in ovarian cancer cells, RSC Advances, 2019, 9: 27294-27304.

4. Xiaojing Li*，Hongmin Wang, Jie Ding, Shaozhen Nie, Li Wang, Lili Zhang, Shaoda Ren*, Celastrol strongly inhibits proliferation, migration and cancer stem cell properties through suppression of Pin1 in ovarian cancer cells, European Journal of Pharmacology, 2019, 842: 146-156.

5. Xingxia Liu, Shaoda Ren, Chaozhuo Ge, Kai Cheng, Xiaojing Li, Robert Chunhua Zhao*, Sca1+Lin-CD117- mouse bone marrow-derived mesenchymal stem cells regulate immature dendritic cell maturation by inhibiting TLR4-IRF8 signaling via the Notch-RBP-J pathway, Stem Cells and Development, 2018, 27(8): 556-565.

6. Kun Li, Lei Li, Shuxiang Wang, Xiaojing Li, Tianyi Ma, Dan Liu*, Yongkui Jing*, Linxiang Zhao*, Design and synthesis of novel 2-substituted 11-keto-boswellic acid heterocyclic derivatives as anti-prostate cancer agents with Pin1 inhibition ability, European Journal of Medicinal Chemistry, 2017, 126: 910-919.

7. Xiaojing Li, Yuetong Wang, Yuan Gao, Lei Li, Xin Guo, Dan Liu, Yongkui Jing*, Linxiang Zhao*, Synthesis of methyl 2-cyano-3,12-dioxo-olean-1,9(11)-dien-30-oate analogues to determine the active groups for inhibiting cell growth and inducing apoptosis in leukemia cells, Organic & Biomolecular Chemistry, 2014, 12, 6706-6716.

8. Xiaojing Li, Lei Li, Qingtong Zhou, Shuzhi Zhang, Rui Zhao, Dan Liu, Yongkui Jing*, Linxiang Zhao*, Synthesis of the novel elemonic acid derivatives as Pin1 inhibitors, Bioorganic & Medicinal Chemistry Letters, 2014, 24(24): 5612-5615.